Contact person: Patrick
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Novel Food Supplement “CP1”
Improves Motor Deficit, Cognitive Function and Neurodegeneration in Animal Model of Parkinson’s disease
Abstract
Based on pivotal roles
of oxidative stress, dopaminergic and cholinergic systems on the
pathophysiology of Parkinson’s disease, the searching for functional food for
patients attacked with Parkinson’s disease from Cyperus rotundus and Zingiber
officinale, the substances possessing antioxidant activity and the
suppression effects on monoamine oxidase B (MAO-B) and acetylcholinesterase
(AChE) has been considered. In this study, we aimed to determine the effect of
the combined extract of C.rotundus and Z.officinale (CP1) to
improve motor and memory deficits, neurodegeneration, oxidative stress and
functions of both cholinergic and dopaminergic systems in animal model of PD
induced by 6-OHDA. Male Wistar rats, weighing 180-220 g, were induced
unilateral lesion at right substantia nigra by 6-OHDA and were orally given CP1
at doses of 100, 200 and 300 mg.kg-1 BW for 14 days after 6-OHDA
injection. The results showed that the 6-OHDA rats treated with CP1 increased
spatial memory but decreased neurodegeneration, MDA level and AChE activity in
hippocampus. The decreased motor disorder and neurodegeneration in substantia
nigra together with the enhanced CAT activity but decreased MAO-B activity in
striatum were also observed. The memory enhancing effect of CP1 might occur via
the improved oxidative stress and the enhanced cholinergic function whereas the
effect to improve motor disorder of CP1 might occur via the enhanced
dopaminergic function in striatum by decreasing the degeneration of
dopaminergic neurons and the suppression of MAO-B. Therefore, CP1 is the
potential functional food against Parkinson's disease. However, further
researches in clinical trial and drugs interactions are essential.
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