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Novel Food Supplement “CP1”
Improves Motor Deficit, Cognitive Function and Neurodegeneration in Animal Model of Parkinson’s disease
Based on pivotal roles of oxidative stress, dopaminergic and cholinergic systems on the pathophysiology of Parkinson’s disease, the searching for functional food for patients attacked with Parkinson’s disease from Cyperus rotundus and Zingiber officinale, the substances possessing antioxidant activity and the suppression effects on monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) has been considered. In this study, we aimed to determine the effect of the combined extract of C.rotundus and Z.officinale (CP1) to improve motor and memory deficits, neurodegeneration, oxidative stress and functions of both cholinergic and dopaminergic systems in animal model of PD induced by 6-OHDA. Male Wistar rats, weighing 180-220 g, were induced unilateral lesion at right substantia nigra by 6-OHDA and were orally given CP1 at doses of 100, 200 and 300 mg.kg-1 BW for 14 days after 6-OHDA injection. The results showed that the 6-OHDA rats treated with CP1 increased spatial memory but decreased neurodegeneration, MDA level and AChE activity in hippocampus. The decreased motor disorder and neurodegeneration in substantia nigra together with the enhanced CAT activity but decreased MAO-B activity in striatum were also observed. The memory enhancing effect of CP1 might occur via the improved oxidative stress and the enhanced cholinergic function whereas the effect to improve motor disorder of CP1 might occur via the enhanced dopaminergic function in striatum by decreasing the degeneration of dopaminergic neurons and the suppression of MAO-B. Therefore, CP1 is the potential functional food against Parkinson's disease. However, further researches in clinical trial and drugs interactions are essential.
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